Our R&D mission

From clinical excellence to regenerative innovation

Our research programs are designed to push the boundaries of what is possible in islet cell therapy — improving outcomes for patients today while building the scientific foundation for next-generation regenerative medicine tomorrow. We focus on programs with clear translational pathways from bench to bedside.

Current research priorities

Active R&D programs

Program 01
Islet Yield and Quality Optimization

We are conducting ongoing studies to improve islet recovery and function from stressed and diseased pancreatic organs. This includes refining isolation techniques and developing advanced benchmark assessments and predictive models that better correlate islet characteristics with long-term transplant success.

Refining isolation techniques for stressed and diseased pancreatic tissue
Developing advanced benchmark assessments and predictive models
Correlating islet characteristics with long-term transplant success
Delivering consistently higher yields and improved clinical outcomes for TPIAT patients
Program 02
Pancreatic Progenitor Cell Programs

We are developing proprietary methods to harvest and characterize pancreatic progenitor cells capable of regenerating all components of pancreatic tissue and graft support — including parenchymal, exocrine, and endocrine. These "self" cells represent a promising approach for targeted regeneration, both in vivo and ex vivo.

Developing proprietary methods to harvest and characterize pancreatic progenitor cells
Targeting regeneration of parenchymal, exocrine, and endocrine pancreatic components
Establishing tissue banking protocols for future cell expansion
Building autologous cell replacement capabilities with potential applications in chronic pancreatitis, type 1 diabetes, and type 2 diabetes
Therapeutic applications

Patient populations we are working toward

Our R&D programs are designed with specific patient populations in mind — addressing significant unmet need across multiple pancreatic conditions.

Chronic pancreatitis
Patients with intractable pain and limited therapeutic options who are candidates for total pancreatectomy with islet autotransplantation.
Type 1 diabetes
Patients requiring beta cell replacement through autologous or regenerative cell-based approaches as an alternative to lifelong insulin dependence.
Type 2 diabetes
Future applications leveraging progenitor cell expansion and directed differentiation toward endocrine restoration in type 2 diabetes patients.
Development pipeline

Our translational roadmap

Clinical services
Islet isolation & TPIAT support

Operational clinical islet processing supporting surgical teams performing total pancreatectomy with islet autotransplantation.

In development
Yield optimization platform

Advanced isolation protocols and predictive models for improved islet yield and viability from stressed and diseased tissue.

In development
Progenitor cell & organoid platform

Proprietary progenitor cell harvesting, tissue banking, and directed differentiation toward autologous cell replacement therapy.

IsleNova is an early-stage R&D company. Pipeline programs are in active development. Timelines are subject to regulatory, funding, and scientific milestones.

Interested in our research?

We welcome collaboration with academic institutions, clinical partners, and investors aligned with our mission to advance islet cell therapeutics.

Contact our team →Investor overview →